diff --git a/External/FEXCore/Source/Interface/Core/OpcodeDispatcher.cpp b/External/FEXCore/Source/Interface/Core/OpcodeDispatcher.cpp
index 2fa26a43a..91fadbfc7 100644
--- a/External/FEXCore/Source/Interface/Core/OpcodeDispatcher.cpp
+++ b/External/FEXCore/Source/Interface/Core/OpcodeDispatcher.cpp
@@ -5914,6 +5914,7 @@ void OpDispatchBuilder::InstallHostSpecificOpcodeHandlers() {
     {OPD(1, 0b01, 0xD7), 1, &OpDispatchBuilder::UnimplementedOp},
 
     {OPD(1, 0b01, 0xD8), 1, &OpDispatchBuilder::AVXVectorALUOp<IR::OP_VUQSUB, 1>},
+    {OPD(1, 0b01, 0xD9), 1, &OpDispatchBuilder::AVXVectorALUOp<IR::OP_VUQSUB, 2>},
     {OPD(1, 0b01, 0xDB), 1, &OpDispatchBuilder::AVXVectorALUOp<IR::OP_VAND, 16>},
     {OPD(1, 0b01, 0xDC), 1, &OpDispatchBuilder::AVXVectorALUOp<IR::OP_VUQADD, 1>},
     {OPD(1, 0b01, 0xDD), 1, &OpDispatchBuilder::AVXVectorALUOp<IR::OP_VUQADD, 2>},
diff --git a/External/FEXCore/Source/Interface/Core/OpcodeDispatcher/Vector.cpp b/External/FEXCore/Source/Interface/Core/OpcodeDispatcher/Vector.cpp
index 7eedf9362..31e125e8c 100644
--- a/External/FEXCore/Source/Interface/Core/OpcodeDispatcher/Vector.cpp
+++ b/External/FEXCore/Source/Interface/Core/OpcodeDispatcher/Vector.cpp
@@ -434,6 +434,8 @@ template
 void OpDispatchBuilder::AVXVectorALUOp<IR::OP_VSUB, 8>(OpcodeArgs);
 template
 void OpDispatchBuilder::AVXVectorALUOp<IR::OP_VUQSUB, 1>(OpcodeArgs);
+template
+void OpDispatchBuilder::AVXVectorALUOp<IR::OP_VUQSUB, 2>(OpcodeArgs);
 
 template
 void OpDispatchBuilder::AVXVectorALUOp<IR::OP_VCMPEQ, 1>(OpcodeArgs);
diff --git a/External/FEXCore/Source/Interface/Core/X86Tables/VEXTables.cpp b/External/FEXCore/Source/Interface/Core/X86Tables/VEXTables.cpp
index eb2fc58f3..360a7d9f8 100644
--- a/External/FEXCore/Source/Interface/Core/X86Tables/VEXTables.cpp
+++ b/External/FEXCore/Source/Interface/Core/X86Tables/VEXTables.cpp
@@ -211,7 +211,7 @@ void InitializeVEXTables() {
     {OPD(1, 0b01, 0xD7), 1, X86InstInfo{"VPMOVMSKB",   TYPE_INST, FLAGS_MODRM | FLAGS_XMM_FLAGS | FLAGS_SF_DST_GPR | FLAGS_SF_MOD_REG_ONLY, 0, nullptr}},
 
     {OPD(1, 0b01, 0xD8), 1, X86InstInfo{"VPSUBUSB", TYPE_INST, GenFlagsSameSize(SIZE_128BIT) | FLAGS_MODRM | FLAGS_VEX_1ST_SRC | FLAGS_XMM_FLAGS, 0, nullptr}},
-    {OPD(1, 0b01, 0xD9), 1, X86InstInfo{"VPSUBUSW", TYPE_INST, FLAGS_MODRM | FLAGS_XMM_FLAGS, 0, nullptr}},
+    {OPD(1, 0b01, 0xD9), 1, X86InstInfo{"VPSUBUSW", TYPE_INST, GenFlagsSameSize(SIZE_128BIT) | FLAGS_MODRM | FLAGS_VEX_1ST_SRC | FLAGS_XMM_FLAGS, 0, nullptr}},
     {OPD(1, 0b01, 0xDA), 1, X86InstInfo{"VPMINUB",  TYPE_INST, FLAGS_MODRM | FLAGS_XMM_FLAGS, 0, nullptr}},
     {OPD(1, 0b01, 0xDB), 1, X86InstInfo{"VPAND",    TYPE_INST, GenFlagsSameSize(SIZE_128BIT) | FLAGS_MODRM | FLAGS_VEX_1ST_SRC | FLAGS_XMM_FLAGS, 0, nullptr}},
     {OPD(1, 0b01, 0xDC), 1, X86InstInfo{"VPADDUSB", TYPE_INST, GenFlagsSameSize(SIZE_128BIT) | FLAGS_MODRM | FLAGS_VEX_1ST_SRC | FLAGS_XMM_FLAGS, 0, nullptr}},
diff --git a/unittests/ASM/VEX/vpsubusw.asm b/unittests/ASM/VEX/vpsubusw.asm
new file mode 100644
index 000000000..9cdcae49c
--- /dev/null
+++ b/unittests/ASM/VEX/vpsubusw.asm
@@ -0,0 +1,41 @@
+%ifdef CONFIG
+{
+  "HostFeatures": ["AVX"],
+  "RegData": {
+    "XMM0": ["0x6162636445464748", "0x5152535455565758", "0x6162636445464748", "0x5152535455565758"],
+    "XMM1": ["0x4142434465666768", "0x7172737475767778", "0x4142434465666768", "0x7172737475767778"],
+    "XMM2": ["0x2020202000000000", "0x0000000000000000", "0x0000000000000000", "0x0000000000000000"],
+    "XMM3": ["0x2020202000000000", "0x0000000000000000", "0x2020202000000000", "0x0000000000000000"],
+    "XMM4": ["0x2020202000000000", "0x0000000000000000", "0x0000000000000000", "0x0000000000000000"],
+    "XMM5": ["0x2020202000000000", "0x0000000000000000", "0x2020202000000000", "0x0000000000000000"]
+  },
+  "MemoryRegions": {
+    "0x100000000": "4096"
+  }
+}
+%endif
+
+lea rdx, [rel .data]
+
+vmovaps ymm0, [rdx]
+vmovaps ymm1, [rdx + 32]
+
+vpsubusw xmm2, xmm0, xmm1
+vpsubusw ymm3, ymm0, ymm1
+
+vpsubusw xmm4, xmm0, [rdx + 32]
+vpsubusw ymm5, ymm0, [rdx + 32]
+
+hlt
+
+align 32
+.data:
+dq 0x6162636445464748
+dq 0x5152535455565758
+dq 0x6162636445464748
+dq 0x5152535455565758
+
+dq 0x4142434465666768
+dq 0x7172737475767778
+dq 0x4142434465666768
+dq 0x7172737475767778